The problem with experiments has always been that human beings make the decisions on whether or not the animals have benefitted from the treatment.
The problem with 'Don't Be Afraid of the Dark' was that it was designed to be a PG-13 movie. It was literally a horror movie for a younger generation. I was trying to do the film equivalent of teenage, young adult readers, and when they gave it an R rating, the movie couldn't sustain an R.
I think the problem with people, as they start to mature, they say, 'Rap is a young man's game,' and they keep trying to make young songs. But you don't know the slang - it changes every day, and you're just visiting. So you're trying to be something you're not, and the audience doesn't buy into that.
The problem with the West is that they start with political reform going towards democracy. If you want to go towards democracy, the first thing is to involve the people in decision making, not to make it.
The problem with my mother is that she didn't go to the doctor. And I think by the time she started to show symptoms that something might not be right, and finally went to the doctor, she was so close to her death that she couldn't get the care she had needed. Her big issue was not going to the doctor.
The problem with regional trade agreements is you get picked apart by the first country. Then you negotiate with the second country. You get picked apart. And you go with the third one. You get picked apart again.
The problem with the U.S. foreign policy is that we're just so unbelievably powerful. And when you've got that kind of power, it's very hard not to use it.
The problem with big films is they snowball very rapidly and you can never pull back. It's a pipeline that needs to be fed.
I think the problem with the word 'happiness' is that it sounds fluffy. It sounds like something trivial that we shouldn't be concerned with.
The problem with middle age, at least when it comes to modeling, is you seldom see a model who is past 27, 28. If they use anyone older, then it becomes automatically a 'personality' story.
I wrote seven Myron Bolitar novels in a row, and I never want to write a Myron book where he just solves a crime. Every one of them I want to be personal, and I want him to grow and change. The problem with that is, it makes the series limited, you can't write a series where a guy is always going through some kind of crisis.
The problem with touring isn't the traveling and the shows, it's the vegetal state you get into.
This is the problem with the leaking. This is actually a terrible thing. Let's say I'm firing Michael Short today. The fact that you guys know about it before he does really upsets me as a human being and as a Roman Catholic.
The problem with living in a fast-food nation is that we expect food to be cheap.
The problem with holistic management is it's so profoundly simple, but it's not easy. And it's profoundly simple. You're almost insulting people's intelligence to explain it twice, just about making better decisions of where you want to go in your life, bringing in environmental, social, economic issues simultaneously.
That's the problem with ADHD: I have no focus; I get bored.
The problem with the stigma around mental health is really about the stories that we tell ourselves as a society. What is normal? That's just a story that we tell ourselves.
The problem with a lot of narrative films is that they're not real enough.
The problem with industrial food is zero transparency. The system thrives on the fact that there is no transparency.
I'm a girls' girl. I have guy friends, but the problem with having guy friends is, like, I always get linked to them, and they'll end up in a slideshow of people I've apparently dated on the Internet.
The problem with independent films is that they can be hit or miss. I've seen scripts that have blown me away. But there have to be all the right ingredients in place to make them work: the director, cast, publicity, distribution.
The problem with the literary hothouse of New York City is that people spend so much time looking in the mirror. They go to parties with people who are just like them, and they write novels about people who are just like them. It's limiting.
The problem with literature, with writing, is that it works sometimes in terms of correction of social ills. Other times, it just does not suffice.
I think that the problem with network television is that they cling to the whole business model like they are clinging to the side of a cliff.
The problem with Ebola is that it makes mistakes while it copies itself. The mistakes are actually good for Ebola because they help Ebola change, and as a result of this, as it jumps from one human body to the next, roughly half the time, it's got a mutation.
The problem with having a sense of humor is often that people you use it on aren't in a very good mood.
It's counterproductive. The problem with sentimentality is that it kills the emotion.
The problem with trying to make a film good and have it work for an audience is the problem of trying to tell a story well. The shape or the color of it doesn't matter.
The problem with binge-watching on Netflix is that you lose three days of your life.
I think, very often, we're addicted to procedurals, those good guy/bad guy shows, and the 'problem' with procedurals is they all follow the same formula: The bad guy does his thing, the good guy goes after him, and in most cases, the good guy figures out who did it and catches him.
The problem with being married to an athlete who is, like, 19 feet tall and can just eat, like, 17 burgers at 11 o'clock at night is, you're like, 'I'll have just three of those burgers,' and you think you're being good because he had 19 and you had three!
The problem with wanting the tax code to be 'simpler, fairer,' and 'pro-growth' is that it's impossible to achieve all three at the same time.
I think part of the problem with charity is that it tends to make us view people as helpless victims. I think in the future, we'll look back on charity in the same way that we look back on colonialism today: as a very paternalistic system that doesn't fully recognise the full spectrum of humanity.
It doesn't benefit me to lie to people. They're eventually going to find out the truth, and then where am I? That's the problem with liberalism and socialism, by the way: it has to be propped up by lies.
The problem with existing biology is you change only one or two genes at a time.
The problem with copyright enforcement is that when the parameters aren't incredibly well defined, it means big corporations, who have deeper pockets and better lawyers, can bully people.