My character in 'Running With Scissors' is manic-depressive. She starts out as a wonderfully eccentric person, and then descends into a terrible illness.
Ambition aspires to descend.
In Jenny Offill's remarkable first novel, 'Last Things,' 7-year-old Grace Davitt watches her mother, Anna, descend into madness and tries to make sense of the claustrophobic world that Anna has created for her.
I don't know where the ideas come from, and it's terrifying. They seem to be absolute flukes. When I was in my 20s, I'd walk around with a notebook all the time and make sure I wrote down anything that occurred to me. Now I'm just hoping that some sort of event will descend on me.