It turns out synthesizing DNA is very difficult. There are tens of thousands of machines around the world that make small pieces of DNA - 30 to 50 letters in length - and it's a degenerate process, so the longer you make the piece, the more errors there are.
When I'm doing music and I'm on the road, I love it. But once I'm home, it's very difficult to go back out on the road.
Acting is one industry that is very difficult to plan for. I'd like to continue to do good work.
Two great and terrible truths of war are these: War is easy to enter into, but difficult to end. And ultimately, in war there are no winners.
My first venture was to trade bicycle parts and hosiery yarn. The initial days proved to be difficult, and I earned very little from my business. But I kept at it. Each day, when I retired for the night, I told myself that money would come in the next day.
There are many causes of violent deaths in America - murders and traffic accidents - that we do not approach with the same 'no price too steep, no task too difficult' approach that we take toward al Qaeda.
I found the most difficult thing when you became successful - when I had the record album, it won Album of the Year - that you were cut off from the source of your material. Your material was everyday people, and you were kind of cut off from that, and you had to work at it.
I've seen a lot of women give up after they've had three or four bad gigs in a row. It's very difficult to learn not to take nasty heckles personally.
Writing has taught me a lot - though far from everything - about writing, so as time has passed, it has become more pleasurable if not easier. I've done other things in life, but writing is by a factor of 10 the most difficult among them. And, of course, you never achieve what you set out to achieve, so you must keep on trying to do better.
From the beginning, the HIV/AIDS pandemic has presented very difficult challenges.
If all our agents would abridge their speeches one half, I am satisfied the effect produced would be much greater. The 'art of leaving off' at the right time, and in the right place, is one of the most difficult things to learn.
The study of history reveals that human progress has not been continuous and regular, but intermittent and spasmodic, often depending upon apparently accidental causes. It is difficult to get a cross-section view of society at any given stage.
America believes what's good for us is good for the world. It's very difficult to understand that that's not necessarily true.
It's always difficult when you're on a show that goes for more than a year or a couple of years.
Bringing together the unique expertise of researchers from both NYU and the Technion will hopefully enable us to overcome some of the most difficult challenges in treating cancer patients.
Fiscal conservatism is just an easy way to express something that is a bit more difficult, which is that the size and scope of government, and really the size and scope of politics in our lives, has grown uncomfortable, unwieldy, intrusive and inefficient.
A lot of people think I'm difficult to work with. It's not like I really want to do that much stuff, so it doesn't really matter. I guess I'm somewhat difficult when it comes to comedy.
Acting is a tough, difficult job with long unsociable hours, although it can be a brilliant job, too. I don't want to complain too much, as nurses, farmers and teachers are out working long hours.
I had a very difficult relationship with my father, which ended up okay, but there were many difficult years.
A network neutrality rule could result in mere 'slaps on the wrist' or involve such expensive and difficult litigation procedures that no small company or consumer could ever bring a case.
I think if you're forthright and answer a lot of questions, sometimes you'll get people who won't let you answer the questions, and that makes for a difficult answer.
I got into hula hooping at age six - I hula hooped all day, every day. That was something I was comfortable with, but I never tried walking or singing while hula hooping! It's actually pretty difficult and tiring. But I like challenging myself. It's hard, but it's really fun.
Making movies is difficult and you get disorientated sometimes - even when you're working with fantastic talent.
Protecting national security amounts to looking for needles in a haystack. The work becomes more difficult if the haystack is larger. Restricting immigration generally, and illegal immigration in particular, limits growth in the haystack, and supports protection of national security.
I have started my own foundation. It's called Follow Your Art. It's at its infancy but my goal is to mentor teenage girls through one of the most difficult times in their lives.
Growing up, I would have to watch the other children and learn from my mistakes. I would have to push myself to overcome the things most people don't have to think about. Brushing my teeth was very difficult because of the noise of the brush.
The more freedom I allow myself as a writer to wander, become lost and go into uncertain territory - and I am always trying to go to the more awkward place, the more difficult place - the more frightening it is, because I have no plan.
I don't even know what Instagram is, All of this high-tech stuff is supposed to set us free and make life easier. To me, it makes it more difficult and demanding.
The Premier League is very difficult football and very different to when you play in Europe, but the player has to have experience to adapt, and this is the key point.
It's always difficult to define what jazz is or what jazz isn't. To me, the only definition that I can think of is it's music where a lot of different elements are played at the same time. The harmonic, the melodic... You're pushing the boundaries on every level. That could be true of rhythm and blues as well. I'm a musician.
It is very difficult for me to accept the fact that I am acting in front of the camera.
The task of the mediator is to help the parties to open difficult issues and nudge them forward in the peace process. The mediator's role combines those of a ship's pilot, consulting medical doctor, midwife and teacher.
It's definitely the highest rated pre-school show on Cable. It's difficult to mix markets that way in terms of ratings. It's hard to tell, you know, where channel 12, or Public Television, is.
When a gift is difficult to give away, it becomes even more rare and precious, somehow gathering a part of the giver to the gift itself.
I am becoming increasingly difficult to please as a reader, but I adore being surprised by a really wonderful book, written by someone I've never heard of before.
Cardiac depression is very powerful; it's very black; it's very dark. What I've learned to do is get out of my head and get into my heart. And it just sounds like an easy thing - it was difficult at first - to truly recognize moment to moment how fortunate I am.
