Zitat des Tages über Molekular / Molecular:
Polymeric materials in the form of wood, bone, skin and fibers have been used by man since prehistoric time. Although organic chemistry as a science dates back to the eighteenth century, polymer science on a molecular basis is a development of the twentieth century.
By then, I was making the slow transition from classical biochemistry to molecular biology and becoming increasingly preoccupied with how genes act and how proteins are made.
The hierarchy of relations, from the molecular structure of carbon to the equilibrium of the species and ecological whole, will perhaps be the leading idea of the future.
I naively thought that we could have a molecular definition for life, come up with a set of genes that would minimally define life. Nature just refuses to be so easily quantified.
Owing to the difficulty of dealing with substances of high molecular weight we are still a long way from having determined the chemical characteristics and the constitution of proteins, which are regarded as the principal con-stituents of living organisms.
After realizing that we would eventually be able to build molecular machines that could arrange atoms to form virtually any pattern that we wanted, I saw that an awful lot of consequences followed from that.
I was a close observer of the developments in molecular biology.
Supramolecular chemistry, the designed chemistry of the intermolecular bond, is rapidly expanding at the frontiers of molecular science with physical and biological phenomena.
You can find academic and industrial groups doing some relevant work, but there isn't a focus on building complex molecular systems. In that respect, Japan is first, Europe is second, and we're third.
In 1970, I had begun work on the basic pancreatic trypsin inhibitor which has later become the model compound for the development of protein NMR, molecular dynamics, and experimental folding studies in other laboratories.
I had been impressed by the fact that biological systems were based on molecular machines and that we were learning to design and build these sorts of things.
Right now, I am doing the reverse of molecular gastronomy. I'm working with scientists to find ingredients and produce that are proven to be good for you.
The really big difference is that what you make with a molecular machine can be completely precise, down to the tiniest degree of detail that can exist in the world.
My cooking philosophy, what I try to do, is to make a cuisine where the produce and the product shines, compared to some current trends that are maybe more adding additional things, like molecular cuisine, with a lot of additives and chemicals, which are now showing that they could be bad for your health.
Most people don't really like to pose. It is difficult to get them to be present and relaxed under this kind of molecular scrutiny. I want them to understand I'm not simply painting them: I am painting them within a precise moment in time, as a shadow moves across their eyebrows. Then it is gone. The moment is over.
Manufacturing takes place in very large facilities. If you want to build a computer chip, you need a giant semiconductor fabrication facility. But nature can grow complex molecular machines using nothing more than a plant.
However, it required some years before the scientific community in general accepted that flexibility and disorder are very relevant molecular properties also in other systems.
On the molecular scale, you find it's reasonable to have a machine that does a million steps per second, a mechanical system that works at computer speeds.
Our approach to medicine is very 19th-century. We are still in the dark ages. We really need to get to the molecular level so that we are no longer groping about in the dark.
Molecular gastronomy is not bad... but without sound, basic culinary technique, it is useless.
Although separating mitochondria and microsomes might appear worlds apart from the determination of the molecular weight of macromolecules, certain concepts were common to the two operations and could be usefully transposed from the latter to the former.
Basically, the body does have a vast amount of inbuilt anti-ageing machinery; it's just not 100% comprehensive, so it allows a small number of different types of molecular and cellular damage to happen and accumulate.
During the decade following the discovery of the double-helical structure of DNA, the problem of translation - namely, how genetic information is used to synthesize proteins - was a central topic in molecular biology.
To say that mind is a product or function of protoplasm, or of its molecular changes, is to use words to which we can attach no clear conception.
Molecular collision dynamics has been a wonderful area of research for all practitioners. This is especially true for those who were following the footsteps of pioneers and leaders of the field twenty years ago.
One of the concepts essential to molecular manufacturing is that of a self-replicating manufacturing system. That concept has lagged behind in its acceptance.
Few scientists acquainted with the chemistry of biological systems at the molecular level can avoid being inspired.
A potato can grow quite easily on a very small plot of land. With molecular manufacturing, we'll be able to have distributed manufacturing, which will permit manufacturing at the site using technologies that are low-cost and easily available.
Some of the most significant advances in molecular biology have relied upon the methodology of genetics. The same statement may be made concerning our understanding of immunological phenomena.
The moment I saw the model and heard about the complementing base pairs I realized that it was the key to understanding all the problems in biology we had found intractable - it was the birth of molecular biology.
We can grow crops less expensively because molecular manufacturing technology is inherently low cost.
Gays are the molecular opposites of blacks.
A molecular manufacturing technology will let us build molecular surgical tools, and those tools will, for the first time, let us directly address the problems at the very root level.
The other advantage is that in conventional manufacturing processes, it takes a long time for a factory to produce an amount of product equal to its own weight. With molecular machines, the time required would be something more like a minute.
We have to accept that we are just machines. That's certainly what modern molecular biology says about us.
I don't often meet people who want to suffer cardiovascular disease or whatever, and we get those things as a result of the lifelong accumulation of various types of molecular and cellular damage.
