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Knowing that you're not alone really does make all the difference in the world.
You don't knock television, even if you don't always like what they make of your work. It makes all the difference between being an also-ran writer and very famous.
A faith is something you die for, a doctrine is something you kill for. There is all the difference in the world.
Husbands and wives, have fun with each other. I'm convinced it makes all the difference in the world.
We all have a fear of the unknown what one does with that fear will make all the difference in the world.
When a child knows that he or she is dyslexic, that it's the way their brain is programmed, and it's not their fault, that makes all the difference in the world.
Go on daddy-daughter dates and father-and-sons' outings with your children. As a family, go on campouts and picnics, to ball games and recitals, to school programs, and so forth. Having Dad there makes all the difference.
In rallying every curve, every hill may be different than you thought. That makes it interesting.
The really big difference is that what you make with a molecular machine can be completely precise, down to the tiniest degree of detail that can exist in the world.