I have never been wired to be front and centre of spotlight and ready to dance.
I left 'Wired' before it was sold to Conde Nast and Lycos, so I didn't experience that transition.
Our brains are wired such that it's difficult to take action until we feel at least some level of this emotional state. In fact, performance peaks under the heightened activation that comes with moderate levels of stress. As long as the stress isn't prolonged, it's harmless.
I'm allergic to cats, so I'm psychologically wired to associating kittens with itchy eyes and popping Claritin.
A vast percentage of the human race is literally not wired neurologically to get irony. Well more than half of humanity takes life at face value, which is to me terrifying.
